Neuro-Oncology Ecosystem Mapping & Plasticity

Our lab is interested in understanding how brain tumors develop, evolve, and interact with the surrounding brain environment. We focus particularly on IDH-mutant gliomas and glioblastoma, combining patient-derived models, cerebral organoids, single-cell and spatial omics, whole-brain imaging, and functional experiments to uncover mechanisms of tumor progression, recurrence, and therapeutic resistance. Through this work, we aim to identify new vulnerabilities that may ultimately help improve treatment strategies for patients with brain tumors.

We enjoy working at the interface of different disciplines and building a collaborative, curious, and supportive lab environment where people can ask ambitious questions and develop their own scientific ideas.

Microscopic view of neural tissue.
Organoid characterization after 50 days of maturation by immunostaining of fixed frozen tissue sections.
Fluorescent microscopy image of co-culture of cerebral organoids, iMGs and astrocytoma cells.
Fluorescent microscopy image of co-culture of human microglia cell line HMC3 and patient derived human astrocytoma grade 4 cell line NCH1681 transduced with a shCD44 vector to knock down CD44 expression.
Microscopic view of a biological specimen, showing cellular structures in black and white.